This review of the literature examines evidence-based data on the use of CAM in mood disorders. Studies support the adjunctive role of omega-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid in unipolar and bipolar depression, although manic symptoms are not affected and higher doses are required in patients with resistant bipolar depression and rapid cycling.
Complementary and alternative medicine CAM has been used either alone or in combination with conventional therapies in patients with mood disorders.
Eight references were added during revisions of this manuscript and one citation was deleted see Figure 1. This article has been cited by other articles in PMC.
Despite psychopharmacological advances during the past six decades, the management of major depression and other mood disorders continues to challenge mental health providers. Clinical trials of vitamin B complex, vitamin D, and methylfolate found that, while these were useful in physical illness, results were equivocal in patients with mood disorders.
A search of the PubMed, Medline, Google Scholar, and Quertile databases using keywords was conducted, and relevant articles published in the English language in the peer-reviewed journals over the past two decades were retrieved.
Only papers were retained for further review. In general, CAM is safe and cost-effective, has limited comparative efficacy to modern allopathic treatments, and is well tolerated by patients with physical and mental disorders. Many patients with mood disorders who are dissatisfied with conventional treatment seek other interventions, in particular complementary and alternative medicine CAM.
Thirty-seven articles that described single cases and small case series less than five subjects were also excluded. Dehydroepiandrosterone is effective both in bipolar depression and depression in the setting of comorbid physical disease, although doses should be titrated to avoid adverse effects.
Abstract Mood disorders are a major public health problem and are associated with considerable burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of life.
Omega-3 fatty acids are useful in pregnant women with major depression, and have no adverse effects on the fetus. Currently, although CAM therapies are not the primary treatment of mood disorders, level 1 evidence could emerge in the future showing that such treatments are effective.
Ayurvedic and homeopathic therapies have the potential to improve symptoms of depression, although larger controlled trials are needed. In total, the authors selected articles, which included open-label clinical trials, randomized controlled trials, systematic reviews, and meta-analyses addressing use of CAM in the management of major depression and other mood disorders.
Choline, inositol, 5-hydroxy-L-tryptophan, and N-acetylcysteine are effective adjuncts in bipolar patients. Mind-body-spirit and integrative medicine approaches can be used effectively in mild to moderate depression and in treatment-resistant depression.role of interventions in preventing depressive disorders in high-risk groups.
Several new directions for future research on the prevention of depression in high-risk groups were outlined. RUNNINGHEAD: PERSPECTIVESIN MAJOR DEPRESSIVEDISORDER(MDD) 1 Current research and perspectives in major depressive disorder: A literature review Cooper John Feild Southern Utah University 2.
PERSPECTIVES IN MDD 2 Abstract Major depressive disorder (MDD) is increasing in prevalence throughout the United States.
Depressive disorders are defined by clinically derived standard diagnostic criteria of emotional, behavioral, cognitive, and somatic symptoms, and associated with functional impairment.
They are assessed through structured clinical interviews and observation. CHAPTER II. LITERATURE REVIEW Definitions Generalized anxiety disorders (Anxiety Disorder, GAD) is a condition of a disorder characterized by excessive anxiety and worry and irrational sometimes unrealistic to events.
Literature Review form Disorders. Literature Review billsimas.com This can produce, sustain, or worsen depressive symptoms. It states that there is a relationship between avoidance and depression that is large explained by the mediating role of reduced positive reinforcement.
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